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Pharmacokinetics: Cyanocobalamin is administered intranasally, orally, and parenterally, while hydroxocobalamin is administered only parenterally. Once absorbed, vitamin B12 is highly bound to transcobalamin II, a specific B-globulin carrier protein and is distributed and stored primarily in the liver as coenzyme B12. The bone marrow also stores a significant amount of the absorbed vitamin B12. This vitamin crosses the placenta and is distributed into breast milk. Enterohepatic recirculation conserves systemic stores. The half-life is about 6 days (400 days in the liver). Elimination is primarily through the bile; however, excess cyanocobalamin is excreted unchanged in the urine
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doi: 10.3389/fphar.2020.590855 Received 03 August 2020 Accepted 18 September 2020 Published 15 October 2020 Volume 11 - 2020 Edited by Efstratios Stratikos, National Centre of Scientific Research Demokritos, Greece Reviewed by Marcin Poreba, Wrocław University of Science and Technology, Poland Akira Hattori, Kyoto University, Japan Updates Copyright © 2020 Hallberg and Larhed
